KISS1R - Kisspeptin Receptor | Elisa - Clia - Antibody - Protein

Background:

KISS1R is a G protein-coupled receptor primarily associated with the regulation of reproductive function and the neuroendocrine control of puberty. KISS1R was identified in the early 2000s as the receptor for kisspeptins, a family of peptide hormones derived from the Kisspeptin-1 (KISS1) gene.

KISS1R is expressed in various tissues, including the hypothalamus, pituitary gland, gonads, placenta, and brain regions involved in the control of reproductive function. KISS1R is activated by kisspeptins, including Kisspeptin-10 (metastin), Kisspeptin-13, and other peptide variants derived from the KISS1 gene.In summary, KISS1R plays a crucial role in the regulation of reproductive function, puberty initiation, and sexual maturation through its interaction with kisspeptin ligands. Dysregulation of KISS1R signaling can lead to various reproductive disorders, highlighting its importance as a therapeutic target in reproductive medicine.

Physiological Functions:

• Reproductive Regulation: KISS1R activation plays a central role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis, governing the release of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH).
• Puberty Initiation: KISS1R signaling is essential for the initiation and progression of puberty, as kisspeptin neurons in the hypothalamus increase their activity during puberty, stimulating GnRH release and gonadotropin secretion.
• Sexual Maturation: KISS1R-mediated signaling is critical for sexual maturation, fertility, and reproductive health in both males and females.
• Regulation: KISS1R activity is regulated by various factors, including sex steroids (estrogen, testosterone), neuropeptides, neurotransmitters, and environmental cues.

Clinical Implications:

Pubertal Disorders: Mutations or dysregulation of KISS1R signaling can lead to pubertal disorders such as central precocious puberty (early puberty) or delayed puberty.

Reproductive Disorders: Alterations in KISS1R signaling have been implicated in reproductive disorders such as hypogonadotropic hypogonadism, infertility, and polycystic ovary syndrome (PCOS).

Therapeutic Potential:

• Reproductive Medicine: Targeting KISS1R signaling holds potential for the treatment of pubertal disorders, infertility, and other reproductive conditions.
• Contraception: Modulation of KISS1R activity may offer novel approaches for contraception by regulating gonadotropin secretion and suppressing ovulation.