14-3-3 protein beta/alpha (YWHAB) Antibody
169€ (20 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
14-3-3 protein beta/alpha (YWHAB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx109444
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
14-3-3 protein beta/alpha Antibody is a Rabbit Polyclonal antibody against 14-3-3 protein beta/alpha.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 14-3-3 protein beta/alpha (YWHAB) Immunogen: Recombinant human 14-3-3 protein beta/alpha protein (1-246AA). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/500 - 1/1000, IF/ICC: 1/200 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P31946 |
| Gene ID | 7529 |
| NCBI Accession | NP_003395.1, NM_003404.4 |
| OMIM | 601289 |
| Alias | YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta,14-3-3 alpha,14-3-3 beta |
| Background | Antibody anti-YWHAB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
YWHAB, part of the 14-3-3 protein family, functions as a scaffold protein that binds to phosphorylated serine/threonine-containing motifs, regulating protein localization, stability, and signaling pathways. It is involved in processes such as cell cycle control, DNA damage response, apoptosis, and stress adaptation by interacting with key signaling proteins, including Raf kinases, BAD, and CDC25. YWHAB regulates pathways like MAPK and PI3K/Akt, influencing cellular growth, survival, and metabolism. It is ubiquitously expressed, with high levels in the brain, where it contributes to synaptic plasticity, neuroprotection, and neuronal development. Dysregulation of YWHAB has been associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, as well as cancer, where altered protein interactions promote tumor survival and metastasis. Knockout studies show defects in cellular proliferation, increased apoptosis, and impaired stress responses, highlighting its role in maintaining cellular stability and signaling balance.
Productos relacionados
14-3-3 Protein Beta/Alpha (YWHAB) Antibody
YWHAB Antibody is a Rabbit Polyclonal antibody against YWHAB. This gene encodes a protein belonging to the 14-3-3 family…
Ver producto
14-3-3 Beta (YWHAB) Antibody
Rabbit polyclonal antibody against 14-3-3 beta protein. Immunogen region is Internal.…
Ver producto
14-3-3 Beta/alpha (YWHAB) Antibody
14-3-3 beta/alpha Antibody is a Mouse Monoclonal antibody against Human, Mouse and Rat.…
Ver producto