3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
195€ (20 µl)
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935106861
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name
3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx003422
tested applications
ELISA, WB
Description
HAAO Antibody is a Rabbit Polyclonal antibody against HAAO. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46952 |
| Gene ID | 23498 |
| NCBI Accession | NP_036337.2 |
| Alias | 3-HAO,3-hydroxyanthranilate oxygenase |
| Background | Antibody anti-HAAO |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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