5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1) Antibody
195€ (20 µl)
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935106861
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name
5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001141
tested applications
ELISA, WB, IHC, IF/ICC
Description
PRKAA1 Antibody is a Rabbit Polyclonal antibody against PRKAA1. The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (PRKAA1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000, IHC-P: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13131 |
| Gene ID | 5562 |
| NCBI Accession | NP_006242.5 |
| Background | Antibody anti-PRKAA1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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The mammalian 5-prime-AMP-activated protein kinase(AMPK) appears to play a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. PRKAA1 is also named as AMPK1, ACACA kinase, HMGCR kinase. It is a mammalian homologue of sucrose non-fermenting protein kinase(SNF-1), which belongs to a serine/threonine protein kinase family. It has 2 isoforms produced by alternative splicing.
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