5'-Nucleotidase / CD73 (NT5E) Antibody (FITC)
572€ (100 tests)
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935106861
info@markelab.com
name
5'-Nucleotidase / CD73 (NT5E) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx274672
tested applications
FCM
Description
5'-Nucleotidase, Ecto (NT5E) Antibody (FITC) is a Rabbit Polyclonal Antibody (
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: 5'-Nucleotidase / CD73 (NT5E) Immunogen: abx065055 - Recombinant CD73/NT5E (Trp29-Phe550) expressed in E. coli. |
| Host | Rabbit |
| Reactivity | Rat |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Assay Type | Concentration: 0.51 mg/ml |
| Recommended Dilution | FCM: 5 µl/106 cells in 100 µl. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | PBS, pH 8.0, containing 1% BSA and 0.02% Sodium azide. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at 4°C for 12 months. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase |
| Background | Antibody anti-NT5E |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.
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