A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
442€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432016
tested applications
P-ELISA, WB
Description
AKAP10 Antibody is a Goat Polyclonal antibody against AKAP10.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Immunogen: abx615584 - Internal region: C-RKVKGKEQEKTSD |
| Host | Goat |
| Reactivity | Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/64000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 11216, 56697, 360540 |
| NCBI Accession | NP_009133.2 |
| Alias | AKAP-10,D-AKAP-2,D-AKAP2,PRKA10 |
| Background | Antibody anti-AKAP10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
AKAP10, also known as dual-specific AKAP2 (D-AKAP2), is a dual-targeting scaffold protein that binds to PKA and other signaling proteins at cellular membranes, including mitochondria and plasma membranes. AKAP10 regulates PKA signaling in pathways related to cardiac function, mitochondrial biogenesis, and cellular energy metabolism. Polymorphisms in AKAP10, such as the I646V variant, are associated with altered heart rate, reduced heart rate variability, and an increased risk of arrhythmias, highlighting its importance in cardiovascular homeostasis. AKAP10 also interacts with mitochondrial proteins to regulate energy production, enhancing ATP synthesis and oxidative phosphorylation. AKAP10 has been implicated in apoptosis, where its role in PKA-dependent signaling ensures mitochondrial integrity during cellular stress. Additionally, AKAP10 participates in cell migration and polarity by organizing signaling complexes near the plasma membrane, influencing cytoskeletal reorganization and adhesion dynamics in cancer metastasis.
Related Products
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Peptide
A-Kinase Anchor Protein 10, Mitochondrial (AKAP10) Peptide is a synthetic peptide. This peptide is used in the production of
Ver Producto