Advanced Glycation End Product (AGE) Antibody

Product specifications

Primary Antibodies

Target: Advanced Glycation End Product (AGE)
Immunogen: abx168580 - Native AGE Protein.

Rabbit

General

Concentration: 0.5 mg/ml

WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

AGE

Antibody anti-AGE

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Advanced Glycation End Products (AGEs) are a diverse group of molecules formed through the non-enzymatic reaction of reducing sugars with proteins, lipids, or nucleic acids in a process called glycation. AGEs accumulate under conditions of oxidative stress and hyperglycemia, particularly in diseases like diabetes mellitus, where they are formed in excess. They are commonly found in long-lived proteins such as collagen and elastin, contributing to tissue stiffness and organ dysfunction. AGEs can crosslink proteins, disrupt cellular signaling, and impair extracellular matrix structure. They are also known to interact with specific receptors, such as the AGE receptor (AGER), activating inflammatory and oxidative pathways that lead to chronic conditions such as cardiovascular disease, kidney damage, and neurodegeneration. AGEs are considered major contributors to aging and the progression of age-related diseases, making them significant biomarkers and therapeutic targets.

Related Products

Human Advanced Glycation End Product (AGE) Protein

Advanced Glycation End Products (AGEs) are the result of a chain of chemical reactions after an initial glycation reaction. Glycation is accomplished by the Maillard reaction, which is a multistep process that begins with Schiff base formation between the amine and the carbonyl group on the sugar followed by rearrangement to form Amadori intermediates. AGEs affect nearly every type of cell and molecule in the body, and are thought to be one factor in aging and some age-related chronic diseases. They are also believed to play a causative role in the vascular complications of diabetes mellitus.

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