Alanine--TRNA Ligase, Mitochondrial (AARS2) Antibody
442€ (200 µl)
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935106861
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name
Alanine--TRNA Ligase, Mitochondrial (AARS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432253
tested applications
P-ELISA, WB
Description
AARS2 Antibody is a Goat Polyclonal antibody against AARS2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Alanine--TRNA Ligase, Mitochondrial (AARS2) Immunogen: abx616777 - Internal region, 478-489 AA: C-QHRARQAEPVQK |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 57505 |
| NCBI Accession | NP_065796.1 |
| Alias | AARS2,AARSL,KIAA1270 |
| Background | Antibody anti-AARS2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
AARS2 is an essential mitochondrial enzyme responsible for catalyzing the ligation of alanine to its corresponding tRNA (tRNA^Ala) during mitochondrial protein synthesis. This process is crucial for the translation of mitochondrial-encoded proteins, which are integral components of the oxidative phosphorylation system. Structurally, AARS2 contains a catalytic domain that ensures high specificity for alanine and tRNA^Ala, contributing to the accuracy of mitochondrial protein translation. AARS2 is predominantly expressed in energy-demanding tissues such as the brain, heart, and skeletal muscle, underscoring its role in maintaining mitochondrial function. Mutations in the AARS2 gene have been linked to mitochondrial diseases, including leukodystrophy and cardiomyopathy, which are characterized by impaired mitochondrial protein synthesis and energy production. These conditions highlight the critical importance of AARS2 in cellular energy metabolism and mitochondrial integrity. Emerging research also suggests potential links between AARS2 dysfunction and broader neurodegenerative disorders, making it a significant target for therapeutic exploration.
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