ALK Tyrosine Kinase Receptor (ALK) Antibody
442€ (200 µl)
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935106861
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name
ALK Tyrosine Kinase Receptor (ALK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431093
tested applications
P-ELISA, WB
Description
Alk Antibody is a Goat Polyclonal antibody against Alk.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: ALK Tyrosine Kinase Receptor (ALK) Immunogen: abx616637 - Internal region: C-TETFHPERLESNS |
| Host | Goat |
| Reactivity | Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 238, 11682, 266802 |
| NCBI Accession | NP_031465.2 |
| Alias | CD246 |
| Background | Antibody anti-ALK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The ALK (anaplastic lymphoma kinase) gene encodes a receptor tyrosine kinase, which is a type of cell surface receptor that plays a role in signaling pathways involved in cell growth, proliferation, and differentiation. The ALK protein belongs to the insulin receptor superfamily and is normally expressed in specific tissues during embryonic development, where it helps regulate normal cell growth and development. While ALK expression is typically limited to certain tissues during development, aberrant activation of the ALK gene can occur in various cancers due to chromosomal rearrangements, gene amplification, or activating mutations. These alterations lead to the overexpression or constitutive activation of the ALK protein, contributing to oncogenesis (the formation of cancer).The most well-known oncogenic alteration involving the ALK gene is the fusion of the ALK gene with another gene, resulting in a chimeric fusion protein with constitutive kinase activity. This fusion protein can drive cellular transformation and tumorigenesis.
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