ALK Tyrosine Kinase Receptor (ALK) Antibody

Product specifications

Primary Antibodies

Target: ALK Tyrosine Kinase Receptor (ALK)
Immunogen: abx615902 - C-PTKKNNPIAKKEPH

Goat

Human

P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

200 µl

P-ELISA, IHC

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

238

NP_004295.2

CD246

Antibody anti-ALK

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

The ALK (anaplastic lymphoma kinase) gene encodes a receptor tyrosine kinase, which is a type of cell surface receptor that plays a role in signaling pathways involved in cell growth, proliferation, and differentiation. The ALK protein belongs to the insulin receptor superfamily and is normally expressed in specific tissues during embryonic development, where it helps regulate normal cell growth and development. While ALK expression is typically limited to certain tissues during development, aberrant activation of the ALK gene can occur in various cancers due to chromosomal rearrangements, gene amplification, or activating mutations. These alterations lead to the overexpression or constitutive activation of the ALK protein, contributing to oncogenesis (the formation of cancer).The most well-known oncogenic alteration involving the ALK gene is the fusion of the ALK gene with another gene, resulting in a chimeric fusion protein with constitutive kinase activity. This fusion protein can drive cellular transformation and tumorigenesis.

Related Products

ALK Tyrosine Kinase Receptor (ALK) Peptide

ALK Tyrosine Kinase Receptor (ALK) Peptide is a synthetic peptide. This peptide is used in the production of

Ver Producto