AlkB Homolog 4, Lysine Demethylase (ALKBH4) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
AlkB Homolog 4, Lysine Demethylase (ALKBH4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027008
tested applications
ELISA, WB
Description
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: AlkB Homolog 4, Lysine Demethylase (ALKBH4) Immunogen: KLH-conjugated synthetic peptide between 88-117 amino acids from the Central region of human ALKBH4. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 33.8 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NXW9 |
| Alias | ALKBH4,ABH4 |
| Background | Antibody anti-ALKBH4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ALKBH4 is a nuclear enzyme that functions as a lysine demethylase, specifically targeting methylated lysine residues on non-histone proteins. ALKBH4 plays a critical role in cytoskeletal dynamics, particularly by demethylating actin, which regulates actin filament assembly and cellular motility. Its activity ensures proper cytokinesis, cell shape maintenance, and migration during mitosis and development. ALKBH4 also participates in DNA repair and gene regulation by interacting with other proteins involved in chromatin remodeling and transcription. Dysregulation of ALKBH4 is linked to defects in cell division, genomic instability, and impaired cellular motility, contributing to developmental abnormalities and cancer progression. In cancer biology, ALKBH4’s regulation of cytoskeletal dynamics has been shown to promote cancer cell invasion and metastasis. Its role in demethylating non-histone proteins distinguishes ALKBH4 from other ALKB family members, highlighting its importance in post-translational modification and cellular homeostasis.
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