Alsin (ALS2) Antibody
442€ (200 µl)
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name
Alsin (ALS2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430481
tested applications
P-ELISA, IHC
Description
Alsin Antibody is a Goat Polyclonal antibody against Alsin.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Alsin (ALS2) Immunogen: abx269113 - C-Terminus: LKACYYQIQREKLN |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 57679 |
| NCBI Accession | NP_065970.2 |
| Alias | ALS2,ALS2CR6 |
| Background | Antibody anti-ALS2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ALS2, also known as Alsin, refers to a gene that encodes a protein called Alsin. Mutations in the ALS2 gene are associated with a rare autosomal recessive form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord. The ALS2 gene provides instructions for producing the Alsin protein, which is involved in various cellular functions, including the regulation of endosome trafficking, maintenance of the cytoskeleton, and protection against oxidative stress. Alsin is particularly important for the health and function of motor neurons, the nerve cells that control voluntary muscle movement. Mutations in the ALS2 gene can lead to dysfunctional or truncated forms of the Alsin protein, which can disrupt normal cellular processes and contribute to the degeneration of motor neurons seen in ALS. However, it's worth noting that ALS2 mutations are relatively rare and account for only a small percentage of ALS cases.
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