APC antibody
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935106861
info@markelab.com
name
APC antibody
category
Primary Antibodies
provider
FineTest
reference
FNab00473
tested applications
ELISA, WB, IHC
Description
Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor(HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | adenomatous polyposis coli (APC) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 300 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P25054 |
| Gene ID | 324 |
| Alias | Adenomatous polyposis coli protein (Protein APC),Deleted in polyposis 2.5,APC,DP2.5 |
| Background | Antibody anti-APC |
| Status | RUO |
| Note | Mol. Weight 300 kDa |
Descripción
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