CASP3 antibody
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935106861
info@markelab.com
name
CASP3 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09938
tested applications
ELISA, IHC, WB,IF
Description
Caspase 3, also named as CPP32, SCA-1 and Apopain, belongs to the peptidase C14A family. Caspase 3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase(PARP) at a '216-Asp-|-Gly-217' bond. Caspase 3 cleaves and activates sterol regulatory element binding proteins(SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6,-7 and-9. Caspase 3 is involved in the cleavage of huntingtin. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | caspase 3, apoptosis-related cysteine peptidase (CASP3) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:50-1:300; IF: 1:50-1:200 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2G7 |
| Observed MW | 32-35 kDa, 19 kDa, 17 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | protein A+G purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB,IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P42574 |
| Gene ID | 836 |
| Alias | Caspase-3 (CASP-3),Apopain,Cysteine protease CPP32 (CPP-32),Protein Yama,SREBP cleavage activity 1 (SCA-1),Caspase-3 subunit p17,Caspase-3 subunit p12,CASP3,CPP32 |
| Background | Antibody anti-CASP3 |
| Status | RUO |
| Note | Mol. Weight 32-35 kDa, 19 kDa, 17 kDa |
Descripción
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