CASP2 antibody
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935106861
info@markelab.com
name
CASP2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab098281
tested applications
ELISA, WB
Description
CASP2(Caspase-2) is also named as ICH1, NEDD2 and belongs to the peptidase C14A family.It is involved in the activation cascade of caspases responsible for apoptosis execution and might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.It has 2 isoforms produced by alternative splicing and can exists almost as a dimer in solution(PMID:15865942).This antibody can recognize the 32 kDa pro-caspase 2 as well as 18 kDa cleaved-caspase 2.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Caspase 2 (CASP2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1:1000-1:6000 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2B10 |
| Observed MW | 18, 32, 50 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P42575 |
| Gene ID | 835 |
| Alias | Caspase-2 (CASP-2),Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2),Protease ICH-1,Caspase-2 subunit p18,Caspase-2 subunit p13,Caspase-2 subunit p12,CASP2,ICH1,NEDD2 |
| Background | Antibody anti-CASP2 |
| Status | RUO |
| Note | Mol. Weight 18, 32, 50 kDa |
Descripción
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CASP2 antibody
This gene encodes a member of the cysteine-aspartic acid protease(caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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