DKK1 antibody
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935106861
info@markelab.com
name
DKK1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab02401
tested applications
ELISA, WB, IF, IHC
Description
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | dickkopf homolog 1 (DKK1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 30-35 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O94907 |
| Gene ID | 22943 |
| Alias | Dickkopf-related protein 1 (Dickkopf-1, Dkk-1, hDkk-1),SK,DKK1 |
| Background | Antibody anti-DKK1 |
| Status | RUO |
| Note | Mol. Weight 30-35 kDa |
Descripción
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