RUNX2 antibody
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935106861
info@markelab.com
name
RUNX2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07536
tested applications
ELISA, WB
Description
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element(OCFRE)(By similarity). Inhibits KAT6B-dependent transcriptional activation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | runt-related transcription factor 2 (RUNX2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 70 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13950 |
| Gene ID | 860 |
| Alias | Runt-related transcription factor 2,Acute myeloid leukemia 3 protein,Core-binding factor subunit alpha-1 (CBF-alpha-1),Oncogene AML-3,Osteoblast-specific transcription factor 2 (OSF-2),Polyomavirus enhancer-binding protein 2 alpha A subunit (PEA2-alpha A, PEBP2-alpha A),SL3-3 enhancer factor 1 alpha A subunit,SL3/AKV core-binding factor alpha A subunit,RUNX2,AML3,CBFA1,OSF2,PEBP2A |
| Background | Antibody anti-RUNX2 |
| Status | RUO |
| Note | Mol. Weight 50-60 kDa |
Descripción
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