TUBB3-specific antibody
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Description
TUBB3, the class III β tubulin or Tuj1, is selectively expressed in testis and neurons of the central and peripheral nervous system. It has been widely used as a marker for neurons. Aberrant expression of TUBB3 has also been found in various tumors of non-neural origin and can be used as a biomarker for cancer aggressiveness and a marker for the tendency to respond poorly to chemotherapy. This antibody is specific to TUBB3 but not cross-react with other tubulin isoforms.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | tubulin, beta 3 (TUBB3) |
| Host | Mouse |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:5000-1:30000; IHC: 1:50-1:300; IF: 1:50-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 2A10 |
| Observed MW | 50-55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | protein A+G purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q13509 |
| Gene ID | 10381 |
| Alias | Tubulin beta-3 chain,Tubulin beta-4 chain,Tubulin beta-III,TUBB3,TUBB4 |
| Background | Antibody anti-TUBB3 |
| Status | RUO |
| Note | Mol. Weight 50-55 kDa |
Descripción
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There are five tubulins in human cells: alpha, beta, gamma, delta, and epsilon. Tubulins are conserved across species. They form heterodimers, which multimerize to form a microtubule filament. An alpha and beta tubulin heterodimer is the basic structural unit of microtubules. The heterodimer does not come apart, once formed. The alpha and beta tubulins, which are each about 55 kDa MW, are homologous but not identical. Alpha and beta tubulins have been widely used as loading controls. Tubulin expression may vary according to resistance to antimicrobial and antimitotic drugs.
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