Apolipoprotein A-I (APOA1) Antibody
286€ (100 µl)
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935106861
info@markelab.com
name
Apolipoprotein A-I (APOA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131723
tested applications
WB, IHC
Description
Apolipoprotein A-I (APOA1) Antibody is a Mouse monoclonal against Apolipoprotein A-I (APOA1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Apolipoprotein A-I (APOA1) Immunogen: abx065401 - Recombinant Rabbit APOA1 (Asp25-Gln265) expressed in E. coli |
| Host | Mouse |
| Reactivity | Rabbit |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 0.01-3 µg/ml, IHC: 5-30 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P09809 |
| Gene ID | 100009253 |
| Alias | Apo A1,Apo-A1,apo(a), apolipoprotein A1, Apolipoprotein A-I,HPALP2,APOA1,Apolipoprotein AI |
| Background | Antibody anti-APOA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
APOA1 is the primary protein component of high-density lipoprotein (HDL), often referred to as "good cholesterol," where it plays a crucial role in reverse cholesterol transport. APOA1 facilitates the removal of cholesterol from peripheral tissues and delivers it to the liver for excretion via bile, thus protecting against atherosclerosis and cardiovascular disease. APOA1 is also an activator of lecithin-cholesterol acyltransferase (LCAT), an enzyme critical for HDL maturation and cholesterol esterification. Mutations in the APOA1 gene can result in familial HDL deficiency or amyloidosis, leading to cardiovascular dysfunction and systemic deposits of amyloid fibrils. As a key modulator of lipid metabolism, APOA1 is a major therapeutic target for managing dyslipidemia and reducing cardiovascular risk.
Related Products
Rabbit Apolipoprotein A-I (APOA1) Protein
Rabbit Apolipoprotein A-I (APOA1) is a recombinant Rabbit protein expressed in E. coli.
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