Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431855
tested applications
P-ELISA, WB, IHC, IF/ICC
Description
AIFM1 Antibody is a Goat Polyclonal antibody against AIFM1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Inducing Factor 1, Mitochondrial (AIFM1) Immunogen: abx617278 - C-Terminus: C-NEVAKLFNIHED |
| Host | Goat |
| Reactivity | Human, Mouse, Rat, Pig |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, IF/ICC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9131, 26926, 83533 |
| NCBI Accession | NP_004199.1, NP_665811.1, NP_665812.1, NP_001124318.1 |
| Alias | AIFM1,AIF,CMT2D,CMTX4,COWCK |
| Background | Antibody anti-AIFM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
AIFM1 is a key mitochondrial protein that mediates caspase-independent apoptosis while also playing essential roles in mitochondrial energy metabolism. Located in the mitochondrial intermembrane space, AIFM1 translocates to the nucleus in response to apoptotic stimuli, where it induces chromatin condensation and large-scale DNA fragmentation. This translocation is triggered by mitochondrial outer membrane permeabilization during cellular stress. Beyond its apoptotic function, AIFM1 is crucial for maintaining mitochondrial respiratory chain integrity and supporting cellular energy homeostasis. Mutations in the AIFM1 gene have been implicated in neurodegenerative disorders and mitochondrial encephalomyopathies, highlighting its dual role in apoptosis and bioenergetics. Its regulation and activity are critical for cellular fate, as dysregulation can lead to either excessive apoptosis, contributing to degenerative diseases, or impaired apoptosis, facilitating cancer progression.
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