Apoptosis Regulator Bcl-2 (BCL2) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Apoptosis Regulator Bcl-2 (BCL2) Antibody is a Rabbit monoclonal against Apoptosis Regulator Bcl-2 (BCL2).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Regulator Bcl-2 (BCL2) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified from cell culture supernatant by protein A/G chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | IHC, WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% BSA, 50% Glycerol, 0.05% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2°C to 8°C up to 2 weeks. Aliquot and store at -20°C for up to 1 year, or at -80°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10415 |
| Gene ID | 596 |
| NCBI Accession | NP_000624.2, NP_000648.2, XP_047293689.1 |
| Background | Antibody anti-BCL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Related Products
BCL2 antibody
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Ver ProductoBCL2 antibody
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor(APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release(PubMed:17418785).
Ver Producto