Arginase-1 (ARG1) Antibody

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260€ (50 µg)

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935106861
info@markelab.com
name
Arginase-1 (ARG1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx377320
tested applications
ELISA, WB, IHC

Description

Arginase-1 (ARG1) Antibody is a Rabbit polyclonal antibody for the detection of Human Arginase-1 (ARG1).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Target: Arginase-1 (ARG1)
Immunogen: Recombinant Arginase-1 (Glu44-Lys322) expressed in E. coli.
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Size 1
50 µg
Size 2
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P05089
Gene ID
383
NCBI Accession
NP_000036.2
Background
Antibody anti-ARG1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

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Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical marker of hepatocellular differentiation in fine needle aspiration cytology and a marker of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406).

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