ATP Binding Cassette Subfamily A Member 8 (ABCA8) Antibody
292.5€ (200 µl)
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935106861
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name
ATP Binding Cassette Subfamily A Member 8 (ABCA8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432260
tested applications
P-ELISA
Description
ABCA8 Antibody is a Goat Polyclonal antibody against ABCA8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: ATP Binding Cassette Subfamily A Member 8 (ABCA8) Immunogen: abx615572 - C-Terminus: C-KEQELGDFEEDFD |
| Host | Goat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 10351 |
| NCBI Accession | NP_009099.1 |
| Alias | KIAA0822 |
| Background | Antibody anti-ABCA8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ABCA8 is a member of the ATP-binding cassette transporter family, primarily involved in lipid transport and xenobiotic metabolism. It is highly expressed in the brain, liver, and kidneys, suggesting roles in lipid homeostasis and the clearance of toxins or drugs. ABCA8 is thought to facilitate the transport of cholesterol and sphingolipids across cellular membranes, contributing to cellular lipid regulation. In the brain, ABCA8 has been implicated in myelin formation and neuronal maintenance, where dysregulation may contribute to neurodegenerative diseases. Mutations or altered expression of ABCA8 have been associated with conditions such as multiple sclerosis and certain cancers. Its role in lipid metabolism and potential involvement in drug resistance highlight its importance in both physiological and pathological processes.
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