ATP Binding Cassette Transporter A2 (ABCA2) Antibody

Product specifications

Primary Antibodies

Target: ATP Binding Cassette Transporter A2 (ABCA2)
Immunogen: abx615570 - Internal region: C-KKQSDNLEQQETEP

Goat

Human

Concentration: 0.5 mg/ml

P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

200 µl

Liquid

P-ELISA, IHC

Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

20, 11305, 79248

NP_001597.2, NP_997698.1

MRX,MXR,ABCP,BCRP,BMDP,MXR1,ABC15,BCRP1,CD338

Antibody anti-ABCA2

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

ABCA2 is a member of the ATP-binding cassette (ABC) transporter family, involved in lipid metabolism and intracellular cholesterol transport. It is primarily expressed in the brain, liver, and macrophages, where it plays a role in maintaining cellular lipid homeostasis and the transport of sterols and sphingolipids. Structurally, ABCA2 contains two transmembrane domains and two nucleotide-binding domains, which use ATP hydrolysis to drive lipid translocation across intracellular membranes. ABCA2 is implicated in myelin formation and neuronal function, highlighting its importance in the central nervous system. Dysregulation of ABCA2 expression has been associated with neurodegenerative diseases, such as Alzheimer’s disease, and certain cancers, where it may contribute to drug resistance by altering cellular lipid composition.

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