ATP Binding Cassette Transporter C3 (ABCC3) Antibody
286€ (100 µl)
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935106861
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name
ATP Binding Cassette Transporter C3 (ABCC3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx129112
tested applications
WB
Description
ATP Binding Cassette Transporter C3 Antibody is a Rabbit Polyclonal against ATP Binding Cassette Transporter C3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: ATP Binding Cassette Transporter C3 (ABCC3) Immunogen: abx167050 - Recombinant ABCC3 (Phe1291-Asp1523) expressed in E. coli |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1-5 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15438 |
| Gene ID | 8714 |
| Alias | ABC31,EST90757,MLP2,Multidrug resistance-associated protein 3 |
| Background | Antibody anti-ABCC3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ABCC3, also known as multidrug resistance-associated protein 3 (MRP3), is expressed on the basolateral membrane of hepatocytes, enterocytes, and other epithelial cells. It facilitates the efflux of organic anions, including bile acids, glucuronides, and sulfated metabolites, from cells into the bloodstream for subsequent excretion via the kidneys. ABCC3 is upregulated in conditions where bile flow is impaired, such as cholestasis, serving as a compensatory mechanism to reduce intracellular bile acid toxicity. It also transports drug conjugates and metabolites, playing a critical role in drug resistance and disposition. ABCC3 is highly expressed in tissues such as the liver, intestines, and pancreas, where it contributes to detoxification and cellular protection. Dysregulation of ABCC3 has been linked to altered drug pharmacokinetics and resistance to chemotherapy.
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