Bcl-2-Related Ovarian Killer Protein (BOK) Antibody

Este producto es parte de BOK - BCL2 family apoptosis regulator BOK
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442€ (200 µl)

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935106861
info@markelab.com
name
Bcl-2-Related Ovarian Killer Protein (BOK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431958
tested applications
P-ELISA, IHC

Description

BOK Antibody is a Goat Polyclonal antibody against BOK.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Target: Bcl-2-Related Ovarian Killer Protein (BOK)
Immunogen: abx616379 - Internal region: C-HISLQSEPVVTD
Host
Goat
Reactivity
Human
Assay Type
Concentration: 0.5 mg/ml
Recommended Dilution
P-ELISA: 1/8000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, IHC
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
666, 51800
NCBI Accession
NP_115904.1
Alias
Hbok,BOKL,BCL2L9,Bcl-2-like protein 9,Bcl2-L-9,Bcl-2-related ovarian killer protein
Background
Antibody anti-BOK
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

Bcl-2-related ovarian killer protein (BOK) is a pro-apoptotic member of the Bcl-2 family that plays a critical role in mediating apoptosis through mitochondrial pathways BOK induces cell death by interacting with other Bcl-2 family members, promoting mitochondrial outer membrane permeabilization and facilitating the release of apoptotic factors like cytochrome c, which activate caspases and lead to programmed cell death Unlike other Bcl-2 family members, BOK is not regulated by the BH3 domain and has a unique role in apoptosis, particularly in ovarian cells BOK’s expression is tightly controlled in healthy tissues, and its dysregulation has been associated with various cancers, where it can influence tumor cell survival, apoptosis resistance, and cancer progression Additionally, BOK has been implicated in regulating neuronal cell death, and its role in maintaining cellular homeostasis under stress conditions suggests it may be a target for therapeutic strategies aimed at inducing apoptosis in tumor cells or protecting against neurodegeneration
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