Bcl2 Associated X Protein (BAX) Antibody

Product specifications

Primary Antibodies

Target: Bcl2 Associated X Protein (BAX)
Immunogen: abx652650 - Recombinant Bcl2 Associated X Protein (Bax)

Rabbit

Mouse

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

WB, IHC, IF/ICC

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

BAX,BCL2L4,BCL2 associated X protein,Bcl-2-like protein 4,Bcl2-L-4

Antibody anti-BAX

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

BCL2 associated X, apoptosis regulator (BAX) is a pro-apoptotic protein that plays a critical role in mitochondrial-mediated apoptosis, a key process in regulating cell death BAX is activated in response to various stress signals, including DNA damage and oxidative stress, and it translocates to the mitochondria, where it promotes the release of cytochrome c, leading to the activation of caspases and cell death BAX functions as a counterpart to anti-apoptotic proteins like BCL2, which inhibit apoptosis BAX's activity is tightly regulated, as excessive activation can lead to uncontrolled cell death and tissue damage Its dysregulation has been implicated in several diseases, including cancer, where reduced BAX activity allows tumor cells to evade apoptosis, contributing to tumor progression and resistance to therapy BAX also has a role in regulating immune responses, particularly in T-cell development and survival, making it crucial for immune system homeostasis Additionally, BAX is involved in neurodegenerative diseases, where excessive cell death in neurons leads to conditions like Alzheimer's and Parkinson's

Related Products

Mouse Bcl2 Associated X Protein (BAX) Protein

Mouse Bcl2 Associated X Protein (Bax) Protein is a recombinant Mouse protein expressed in E. coli.

Ver Producto