Beta-1 Adrenergic Receptor (ADRB1) Antibody
442€ (200 µl)
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935106861
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name
Beta-1 Adrenergic Receptor (ADRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432289
tested applications
P-ELISA, IHC
Description
ADRB1 Antibody is a Goat Polyclonal antibody against ADRB1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Beta-1 Adrenergic Receptor (ADRB1) Immunogen: abx269855 - Internal region: ESDEARRCYNDPK |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 153 |
| NCBI Accession | NP_000675.1 |
| Alias | ADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR |
| Background | Antibody anti-ADRB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.
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