Bradykinin Receptor B1 (BDKRB1) Antibody
442€ (200 µl)
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935106861
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name
Bradykinin Receptor B1 (BDKRB1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432423
tested applications
P-ELISA, WB
Description
Bradykinin receptor B1 Antibody is a Goat Polyclonal antibody against Bradykinin receptor B1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Bradykinin Receptor B1 (BDKRB1) Immunogen: abx615642 - Internal region: KVWELYKQCTPK |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 623 |
| NCBI Accession | NP_000701.2 |
| Alias | BDKRB1,B1BKR,BKR1,B1R,bradykinin receptor,BKB1R,BRADYB1 |
| Background | Antibody anti-BDKRB1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Bradykinin Receptor B1 (BDKRB1) is an inducible GPCR primarily expressed during inflammatory responses and tissue injury. Unlike the constitutively expressed B2 receptor, B1 is induced by pro-inflammatory cytokines, such as IL-1β and TNF-α, in response to chronic inflammation, trauma, or infection. BDKRB1 binds des-Arg9-bradykinin, a bradykinin metabolite, and mediates pro-inflammatory effects, including pain sensitization, vasodilation, and vascular permeability. This receptor plays a pivotal role in chronic pain conditions, such as neuropathic pain and inflammatory hyperalgesia, by sensitizing sensory neurons and enhancing pain signaling. BDKRB1 also contributes to angiogenesis and leukocyte recruitment, facilitating immune responses during infection and injury. In the cardiovascular system, B1 activation is associated with hypertension, vascular remodeling, and endothelial dysfunction. Dysregulation of BDKRB1 signaling is linked to conditions like diabetic complications, chronic inflammatory diseases, and certain cancers, where it can promote tumor growth and metastasis. Targeting BDKRB1 with antagonists has shown promise in preclinical models for managing chronic pain, inflammation, and vascular disorders, making it an emerging target for therapeutic development.
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