C-Type Lectin Domain Family 4, Member C (CLEC4C) Antibody

Product specifications

Primary Antibodies

Target: C-Type Lectin Domain Family 4, Member C (CLEC4C)
Immunogen: Synthetic peptide of human CLEC4C.

Rabbit

Human

ELISA: 1/1000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Antigen Affinity Chromatography.

50 µl

100 µl

Liquid

ELISA, IHC

PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q8WTT0

170482

C-type lectin domain family 4 member C,DLEC,HECL,BDCA2,CD303,BDCA-2,CLECSF7,CLECSF11,Blood dendritic cell antigen 2,Dendritic lectin

Antibody anti-CLEC4C

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

CLEC4C, also known as CD303 or BDCA-2 (Blood Dendritic Cell Antigen 2), is a member of the C-type lectin domain family 4 of receptors and is highly specific to plasmacytoid dendritic cells (pDCs), a subset of immune cells that are crucial for antiviral responses. CLEC4C serves as a pattern recognition receptor (PRR), identifying and binding to carbohydrate structures on pathogens, which helps initiate immune responses. Unlike many other C-type lectins that are broadly expressed on various immune cells, CLEC4C is primarily expressed on pDCs, a unique cell type specializing in the secretion of large quantities of type I interferons (IFN-α/β) in response to viral infections. This exclusive expression gives CLEC4C a unique role in the immune system, particularly in antiviral defense and modulating immune responses in both innate and adaptive immunity. CLEC4C is involved in immune modulation by inhibiting type I interferon production when cross-linked, adding another layer to immune regulation. It is studied extensively in the context of autoimmune diseases and chronic infections because of its involvement in pDC-mediated responses. Furthermore, its specific expression on pDCs has made CLEC4C a target for therapeutic interventions aimed at modulating pDC activity in autoimmune diseases and certain cancers.

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