Calcium Sensing Receptor (CASR) Antibody
195€ (20 µl)
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935106861
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name
Calcium Sensing Receptor (CASR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001232
tested applications
WB, IHC
Description
CASR Antibody is a Rabbit Polyclonal antibody against CASR. CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Calcium Sensing Receptor (CASR) Immunogen: Synthetic peptide corresponding to CASR. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 121 kDa Observed MW: 130-260 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q969H0 |
| Gene ID | 846 |
| NCBI Accession | NP_000379.3 |
| Alias | CASR,CAR,EIG8,FHH,FIH,GPRC2A,HHC,HHC1,HYPOC1,NSHPT,PCAR1,hCasR |
| Background | Antibody anti-CASR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Calcium Sensing Receptor (CASR) is a G-protein-coupled receptor (GPCR) that plays a central role in maintaining systemic calcium homeostasis. CASR is primarily expressed in the parathyroid glands, kidneys, and bone, where it detects minute changes in extracellular calcium levels. Activation of CASR in the parathyroid glands leads to the inhibition of parathyroid hormone (PTH) secretion, a key regulator of calcium and phosphate balance. This prevents excessive calcium resorption from bone and calcium reabsorption in the kidneys, helping to maintain optimal calcium concentrations. CASR signaling in the renal tubules enhances calcium excretion and regulates water balance, contributing to fluid and electrolyte homeostasis. Beyond calcium regulation, CASR influences processes such as bone remodeling, insulin secretion, and vascular smooth muscle tone, playing critical roles in skeletal, metabolic, and cardiovascular health. Mutations in the CASR gene are linked to disorders such as familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), conditions characterized by dysregulated calcium sensing and metabolism. CASR is also implicated in diseases like chronic kidney disease (CKD), where calcium-phosphate imbalances are common, and in cancers such as breast cancer, where CASR promotes tumor cell growth and metastasis to bones. Therapeutically, CASR modulators like calcimimetics are used to treat secondary hyperparathyroidism and hypercalcemia in conditions such as primary hyperparathyroidism. Research into CASR signaling continues to reveal its broader roles in inflammation, cell proliferation, and immune response, highlighting its importance as a potential therapeutic target for metabolic and bone disorders.
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