Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) Antibody (Biotin)

Product specifications

Primary Antibodies

Target: Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5)
Immunogen: abx065719 - Recombinant CEA (Pro93-Val221) expressed in E. coli

Rabbit

Human

Concentration: 0.24 mg/ml

WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Biotin

IgG

Purified by antigen-specific affinity chromatography.

200 µl

1 ml

Liquid

WB, IHC, IF/ICC

PBS, pH 7.4, containing 0.02% sodium azide, 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P06731

1048

CEA,CD66eMeconium antigen 100,Carcinoembryonic antigen

Antibody anti-CEACAM5

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

CEACAM5, also known as carcinoembryonic antigen (CEA), is a glycoprotein member of the immunoglobulin superfamily that plays a prominent role in cell adhesion, immune modulation, and intercellular signaling. It is highly expressed in epithelial tissues and is overexpressed in various cancers, including colorectal, pancreatic, and lung cancers, where it is used as a tumor marker for diagnosis, prognosis, and monitoring therapeutic responses. CEACAM5 mediates homophilic and heterophilic adhesion, influencing cellular aggregation, invasion, and metastasis. It interacts with other CEACAM family members and cell surface receptors to regulate signaling pathways involved in cell proliferation, migration, and immune evasion. Structurally, CEACAM5 contains multiple immunoglobulin-like domains, a glycosylphosphatidylinositol (GPI) anchor, and extensive glycosylation sites that contribute to its functional diversity. In cancer, CEACAM5 promotes tumor progression by enhancing adhesion to extracellular matrix components and modulating immune responses, such as inhibiting T-cell activation. Therapeutic strategies targeting CEACAM5, including monoclonal antibodies and vaccines, are under development to exploit its role as a biomarker and driver of tumor progression. CEACAM5 also plays roles in physiological processes like epithelial cell polarity and tissue homeostasis, reflecting its multifaceted importance.

Related Products

Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) Protein

Human CEACAM5 is a recombinant Human protein expressed in E. coli.

Ver Producto