CASP8 And FADD-Like Apoptosis Regulator (CFLAR) Antibody
234€ (5 µg)
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Name
CASP8 And FADD-Like Apoptosis Regulator (CFLAR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137446
Description
CASP8 And FADD-Like Apoptosis Regulator (CFLAR) Antibody is a Mouse Monoclonal antibody against CASP8 And FADD-Like Apoptosis Regulator (CFLAR).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: CASP8 And FADD-Like Apoptosis Regulator (CFLAR) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 100 µg |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP |
| Background | Antibody anti-CFLAR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CASP8 and FADD-like apoptosis regulator (CFLAR), also known as c-FLIP, is an important regulatory protein that modulates apoptosis, particularly in response to death receptor signaling. CFLAR is structurally related to the caspase family but lacks protease activity, allowing it to inhibit caspase-8 activation in the death receptor pathway. By binding to the death-inducing signaling complex (DISC), CFLAR blocks the activation of downstream apoptotic signaling, effectively acting as an inhibitor of apoptosis. This inhibition allows cells to evade cell death, and as such, CFLAR has been implicated in promoting cell survival in various cancers, as well as playing a role in immune responses.
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