CDK7/Cyclin-H Assembly Factor (MNAT1) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
CDK7/Cyclin-H Assembly Factor (MNAT1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001566
tested applications
WB
Description
MNAT1 Antibody is a Rabbit Polyclonal antibody against MNAT1. The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CDK7/Cyclin-H Assembly Factor (MNAT1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51948 |
| Gene ID | 4331 |
| NCBI Accession | NP_002422.1 |
| Background | Antibody anti-MNAT1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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MNAT1 antibody
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase(CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain(CTD) of its large subunit(POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
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