Cell Adhesion Molecule With Homology To L1CAM (CHL1) Antibody

Product specifications

Primary Antibodies

Target: Cell Adhesion Molecule With Homology To L1CAM (CHL1)
Immunogen: abx166901 - Recombinant CHL1 (Pro35-Glu328) expressed in E. coli

Rabbit

Human

Concentration: 0.22 mg/ml

WB: 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.

100 µl

200 µl

1 ml

Liquid

WB

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.

Shipped within 5-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

O00533

10752

CAL, L1CAM2,Close homolog of L1,Neural cell adhesion molecule L1-like protein

Antibody anti-CHL1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

CHL1, a member of the immunoglobulin superfamily, is closely related to L1CAM and plays a pivotal role in nervous system development and plasticity. CHL1 is expressed predominantly in the brain and spinal cord, where it mediates axon guidance, neuronal migration, and synapse formation by promoting cell-cell and cell-matrix adhesion. It contains extracellular immunoglobulin-like and fibronectin type III domains, facilitating its interactions with extracellular matrix proteins and other cell adhesion molecules. CHL1 is critical for axonal outgrowth, particularly in commissural axons, and contributes to neural circuit establishment during embryonic development. Mutations or altered expression of CHL1 have been linked to neurodevelopmental disorders, including schizophrenia and intellectual disability. CHL1 also interacts with intracellular signaling proteins, influencing cytoskeletal dynamics and neuronal polarity. Emerging evidence suggests that CHL1 may play a role in peripheral nervous system repair and regeneration following injury. Beyond the nervous system, CHL1 is implicated in cancer biology, where its dysregulation has been associated with tumor cell invasion and metastasis, particularly in glioblastoma. Its dual role in normal development and disease highlights CHL1 as a potential therapeutic target for both neurological and oncological conditions.

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