DCC-Interacting Protein 13-Alpha (APPL1) Antibody (FITC)
169€ (20 µg)
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Name
DCC-Interacting Protein 13-Alpha (APPL1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx312158
Description
APPL1 Antibody (FITC) is a Rabbit Polyclonal against APPL1 conjugated to FITC.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DCC-Interacting Protein 13-Alpha (APPL1) Immunogen: Recombinant human DCC-interacting protein 13-alpha protein (214-495AA). |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKG1 |
| Gene ID | 26060 |
| OMIM | 604299 |
| Alias | APPL1, APPL, DIP13alpha, MODY14, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
| Background | Antibody anti-APPL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
APPL1 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 1) is a protein involved in several cellular processes, particularly in intracellular signaling pathways. It is a key regulator of cellular trafficking, endocytosis, and membrane receptor recycling. APPL1 contains both a pleckstrin homology (PH) domain and a leucine zipper, which are important for its interaction with phosphotyrosine residues on target proteins. These interactions are crucial for cellular communication and the regulation of various signaling pathways that control cellular homeostasis and growth. APPL1 plays a role in the regulation of insulin signaling and is involved in the formation of signaling complexes that regulate cell survival, metabolism, and proliferation. Its role in these pathways makes it an important protein in studies related to cancer, metabolic disorders, and neurodegenerative diseases.
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