Death Domain-Associated Protein 6 Phospho-Ser668 (DAXX pS668) Antibody
221€ (50 µg)
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Name
Death Domain-Associated Protein 6 Phospho-Ser668 (DAXX pS668) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324383
Tested Applications
ELISA, WB, IHC
Description
DAXX (pS668) Antibody is a Rabbit Polyclonal against DAXX (pS668).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Death Domain-Associated Protein 6 Phospho-Ser668 (DAXX pS668) Immunogen: Synthesized peptide derived from human Daxx around the phosphorylation site of S668. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UER7 |
| Gene ID | 1616 |
| Alias | DAXX, BING2, DAP6, EAP1, death-domain associated protein, death domain associated protein, SMIM40 |
| Background | Antibody anti-DAXX |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Death-Associated Protein 6 (DAXX) is a multifunctional protein involved in apoptosis regulation, transcriptional control, and chromatin remodeling. Initially identified as a Fas-binding protein, DAXX can mediate apoptotic signals in response to Fas receptor activation, playing a role in programmed cell death. In addition to its role in apoptosis, DAXX functions as a transcriptional co-repressor, interacting with various transcription factors to modulate gene expression. DAXX is also a key component of the chromatin remodeling machinery, where it interacts with histone chaperones and contributes to histone deposition and nucleosome assembly. It is localized to promyelocytic leukemia nuclear bodies (PML-NBs) and telomeres, where it participates in DNA damage responses and telomere maintenance. Dysregulation of DAXX is linked to cancer, as it can act as a tumor suppressor or promoter depending on the cellular context. Mutations in DAXX are frequently observed in pancreatic neuroendocrine tumors and other cancers, where they contribute to genomic instability and altered gene expression. DAXX is being investigated as a therapeutic target due to its diverse roles in apoptosis, chromatin dynamics, and tumorigenesis.
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