Dedicator of Cytokinesis 1 (DOCK1) Antibody
442€ (200 µl)
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name
Dedicator of Cytokinesis 1 (DOCK1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431929
tested applications
WB
Description
DOCK1 Antibody is a Goat Polyclonal antibody against DOCK1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Dedicator of Cytokinesis 1 (DOCK1) Immunogen: abx269057 - C-Terminus: C-TTRKQTSVDSGIVQ |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 1793, 330662 |
| NCBI Accession | NP_001371.1 |
| Alias | DOCK1, DOCK180, ced5, Dock180, dedicator of cytokinesis 1 |
| Background | Antibody anti-DOCK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
DOCK1, also known as DOCK180, is a GEF that activates Rac1 GTPase, regulating cytoskeleton rearrangement and cell migration. It forms a DOCK1–ELMO–Crk complex for Rac1 activation, driving lamellipodia formation and cell motility. DOCK1 is crucial for phagocytosis, cell polarity, neural crest migration, and cardiovascular development. Overexpression links to cancer metastasis by promoting tumor motility. It localizes to cytoplasm and membrane ruffles during migration and is regulated via phosphorylation and scaffold interactions. Knockout studies in mice reveal its role in embryonic viability, neuronal differentiation, and immune responses, highlighting its importance in cell adhesion and morphology.
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