Deoxyribonuclease-1 (DNASE1) Antibody
312€ (60 µl)
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935106861
info@markelab.com
name
Deoxyribonuclease-1 (DNASE1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001975
tested applications
IF/ICC
Description
DNASE1 Antibody is a Rabbit Polyclonal antibody against DNASE1. This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Deoxyribonuclease-1 (DNASE1) |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24855 |
| Gene ID | 1773 |
| NCBI Accession | NP_005214.2 |
| Background | Antibody anti-DNASE1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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