Docking Protein 4 (DOK4) Protein
234€ (5 µg)
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Name
Docking Protein 4 (DOK4) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx261283
Tested Applications
SDS-PAGE
Description
DOK4 is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | DOK4 |
| Assay Type | Activity: Not tested |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q8TEW6 |
| Alias | Downstream of tyrosine kinase 4,Insulin receptor substrate 5,IRS-5,IRS5 |
| Background | Protein DOK4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DOK4 is an adaptor protein belonging to the DOK family, involved in signal transduction downstream of receptor tyrosine kinases, such as RET and insulin receptors. It modulates pathways like MAPK/ERK and PI3K/Akt, influencing cellular proliferation, survival, and differentiation. DOK4 is expressed in tissues like skeletal muscle, adipose tissue, and the nervous system, where it regulates metabolic signaling and cellular responses. It acts as a negative regulator of signaling by binding to SH2 domains and inhibiting downstream activation. Dysregulation of DOK4 is associated with metabolic disorders, insulin resistance, and certain cancers, where it influences cell adhesion and motility.
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