E3 Ubiquitin-Protein Ligase CBL (CBL) Antibody
377€ (100 µg)
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Name
E3 Ubiquitin-Protein Ligase CBL (CBL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231317
Tested Applications
ELISA, WB, IHC
Description
CBL Antibody is a Rabbit Polyclonal against CBL.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E3 Ubiquitin-Protein Ligase CBL (CBL) Immunogen: Cas-Br-M (murine) ecotropic retroviral transforming sequence |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 117 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P22681 |
| Alias | CBL, C-CBL2, FRA11B, NSLL, RNF55 |
| Background | Antibody anti-CBL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CBL is an E3 ubiquitin ligase that plays a crucial role in regulating signal transduction pathways, particularly those associated with receptor tyrosine kinases (RTKs) like the epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR). CBL mediates the ubiquitination of target proteins, leading to their degradation via the proteasome, and regulates the receptor's internalization and downregulation. This process ensures the proper termination of signaling, which is important for cellular processes such as growth, differentiation, and survival. Dysregulation of CBL activity has been implicated in various cancers, as uncontrolled signaling due to deficient ubiquitination can result in unchecked cell proliferation and survival.
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