E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Peptide
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Peptide is a synthetic peptide.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) |
| Host | Synthetic |
| Recommended Dilution | BL (predicted): 0.5 mg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: Internal region: C-RALEGHERQHLE |
| Size 1 | 100 µg |
| Form | Lyophilized Reconstitute in deionized water. |
| Tested Applications | P-ELISA |
| Buffer | Prior to lyophilization: Deionized water. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 84447, 361712 |
| NCBI Accession | NP_115807.1, NP_757385.1 |
| Background | Protein SYVN1 |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Related Products
SYVN1 antibody
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control(ERQC) system also called ER-associated degradation(ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin(HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis.
Ver Producto
Recombinant Human SYVN1
Ver Producto
E3 Ubiquitin-Protein Ligase Synoviolin (SYVN1) Antibody
SYVN1 Antibody is a Rabbit Polyclonal antibody against SYVN1. HRD1is also named as SYVN1(Synovial apoptosis inhibitor 1), KIAA1810. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Two distinct binding sites mediate Hrd1 dimerization or oligomerization, one located within the transmembrane region and another within the cytosolic domain. (PMID:19864457).Western blot analysis detected abundant HRD1 expression in liver and kidney. Mouse liver and spleen expressed Hrd1 as an 85-kD protein(PMID:12646171).This antibody is specific to HRD1.
Ver Producto