ErbB2 Protein
11693.5€ (1 mg)
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Name
ErbB2 Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx061452
Tested Applications
ELISA
Description
ErbB2 Protein is a recombinant Protein. It is produced using HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ErbB2 |
| Host | Human |
| Expression | Recombinant |
| Purification | Purified from HEK293 cells |
| Size 1 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Buffer | Buffer contains no preservative. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2 |
| Background | Protein ERBB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Centrifuge before opening to ensure complete recovery of vial contents. |
Background
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
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