FADD (pS191) Antibody
221€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
FADD (pS191) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx330212
Tested Applications
ELISA, WB, IHC
Description
FADD (pS191) Antibody is a Rabbit Polyclonal against FADD (pS191).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: FADD (pS191) Immunogen: Synthesized peptide derived from human FADD around the phosphorylation site of S191. |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | FADD,GIG3, MORT1,IMD90 |
| Background | Antibody anti-FADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.
Productos relacionados
FAS-Associated Death Domain Protein (FADD) Antibody
FADD Antibody is a Rabbit Polyclonal antibody against FADD. The protein encoded by this gene is an adaptor molecule that…
Ver producto
FADD (Phospho-Ser191) Antibody
Rabbit polyclonal antibody against FADD protein. Immunogen region is C-terminal. Specificity is as follows for the react…
Ver producto
Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibody
Rabbit polyclonal antibody against FADD protein. Immunogen region is C-terminal.…
Ver producto