FAS-Associated Death Domain Protein (FADD) Protein
234€ (2 µg)
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Name
FAS-Associated Death Domain Protein (FADD) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx262999
Tested Applications
SDS-PAGE
Description
FADD is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | FADD |
| Assay Type | Activity: Not tested |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | Q13158 |
| Alias | FADD,GIG3, MORT1,IMD90 |
| Background | Protein FADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.
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