Frizzled Homolog 4 (FZD4) Antibody
442€ (200 µl)
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name
Frizzled Homolog 4 (FZD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432720
tested applications
P-ELISA, IHC
Description
FZD4 Antibody is a Goat Polyclonal antibody against FZD4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Frizzled Homolog 4 (FZD4) Immunogen: abx615857 - Internal region: C-KIRSNLQKDGTKT |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8322 |
| NCBI Accession | NP_036325.2 |
| Alias | FZD4,Fz4,EVR1,FEVR,Fz-4,FzE4,GPC, hFz4,CD344,FZD4S,frizzled receptor 4 |
| Background | Antibody anti-FZD4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
FZD4 is a Wnt receptor that mediates canonical β-catenin-dependent signaling and non-canonical pathways. It is expressed in vascular endothelial cells, the retina, and skeletal tissue, playing a key role in angiogenesis, vascular integrity, and retinal development. FZD4 interacts with Wnt ligands and coreceptors like LRP5/6 to activate β-catenin signaling, which is essential for retinal vascularization and blood-retina barrier maintenance. Mutations in FZD4 are associated with familial exudative vitreoretinopathy (FEVR), a genetic disorder characterized by incomplete retinal vascular development, leading to vision loss. In cancer, FZD4 promotes tumor angiogenesis and metastasis by activating Wnt signaling pathways that support endothelial cell proliferation and survival. Its overexpression has been observed in breast and colorectal cancers, where it enhances angiogenesis and therapy resistance. FZD4 also regulates bone formation and osteoblast differentiation, contributing to skeletal development. Targeting FZD4 and its signaling pathways has therapeutic potential in vascular disorders, cancer, and ocular diseases. Overall, FZD4 is essential for vascular development and maintenance, with dysregulation contributing to angiogenic disorders and tumor progression.
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