Glutamate Metabotropic Receptor 7 (GRM7) Antibody
442€ (200 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Glutamate Metabotropic Receptor 7 (GRM7) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431035
tested applications
P-ELISA, WB
Description
GRM7 Antibody is a Goat Polyclonal antibody against GRM7.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Glutamate Metabotropic Receptor 7 (GRM7) Immunogen: abx615858 - Internal region: NCKLTISGSKKEDT |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 2917, 108073, 81672 |
| NCBI Accession | NP_000835.1, NP_870989.1 |
| Alias | GRM7,GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87, mGluR7,mGlu7a receptor |
| Background | Antibody anti-GRM7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
GRM7, or mGluR7, is a Group III metabotropic glutamate receptor widely expressed in the central nervous system, including the hippocampus, amygdala, and cerebellum. It functions as a presynaptic autoreceptor, coupling to Gi/o proteins to inhibit adenylate cyclase, decrease cAMP production, and suppress glutamate release. GRM7 plays a key role in synaptic plasticity, neuroprotection, and neuronal excitability, contributing to learning, memory, and emotional regulation. Dysregulation of GRM7 signaling is linked to psychiatric and neurological disorders, including anxiety, depression, schizophrenia, and epilepsy, where imbalanced glutamatergic transmission disrupts synaptic function. GRM7 activation has neuroprotective effects, reducing excitotoxicity and oxidative stress in neurodegenerative conditions. Positive allosteric modulators (PAMs) and selective agonists of GRM7 are being explored as therapeutic agents for anxiety, mood disorders, and epilepsy, highlighting its potential in restoring synaptic balance and neuroprotection.
Related Products
Glutamate Metabotropic Receptor 7 (GRM7) Peptide
Glutamate Metabotropic Receptor 7 (GRM7) Peptide is a synthetic peptide. This peptide is used in the production of
Ver Producto