Human 5'-Nucleotidase (NT5E) Protein
169€ (10 µg)
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935106861
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name
Human 5'-Nucleotidase (NT5E) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx169315
tested applications
WB
Description
Human 5'-Nucleotidase (NT5E) Protein is a recombinant protein produced in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 5'-Nucleotidase (NT5E) |
| Host | HEK293 cells |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 58.8 kDa Observed MW (SDS-PAGE): 65 kDa Sequence Fragment: 27-549 AA. Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, containing 20% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store between -20 °C and -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21589 |
| Gene ID | 4907 |
| OMIM | 129190 |
| Alias | NT,En,NT5,NTE,eNT,CD73,E5NT,CALJA,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase |
| Background | Protein NT5E |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The NT5E gene encodes 5'-nucleotidase ecto, also known as CD73, a glycosylphosphatidylinositol (GPI)-anchored enzyme that is crucial in purinergic signaling. It catalyzes the hydrolysis of extracellular nucleotides into nucleosides, with a primary function of converting AMP (adenosine monophosphate) to adenosine. CD73 is expressed on a wide range of cell types, including endothelial cells, epithelial cells, fibroblasts, T cells, and tumor cells. It plays a fundamental role in regulating inflammation, vascular permeability, immune response, and tissue protection under stress conditions such as ischemia. Adenosine generated by CD73 is a potent signaling molecule that binds to adenosine receptors (A1, A2A, A2B, and A3) to mediate various physiological processes, including anti-inflammatory effects, vasodilation, and immunosuppression. In the immune system, CD73 suppresses pro-inflammatory responses and helps in the resolution of inflammation. This dual role makes NT5E a key molecule in both health and disease, especially in pathologies such as cancer, cardiovascular diseases, and chronic inflammatory disorders.
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