Human Activin Receptor Type-2B (ACVR2B) Protein
234€ (10 µg)
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935106861
info@markelab.com
name
Human Activin Receptor Type-2B (ACVR2B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690515
tested applications
SDS-PAGE
Description
Activin Receptor Type-2B (ACVR2B) protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Activin Receptor Type-2B (ACVR2B) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Ser19-Thr134 Tag: C-terminal 6 His tag |
| Origin | Human |
| Observed MW | Calculated MW: 14.4 kDa Observed MW (SDS-PAGE): 25-38 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM PBS, 150 mM NaCl, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q13705 |
| Gene ID | 93 |
| OMIM | 602730, 613751 |
| Alias | Activin receptor type IIB,ACTR-IIB |
| Background | Protein ACVR2B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
ACVR2B is another type II receptor involved in activin and myostatin signaling pathways. It phosphorylates type I receptors (e.g., ACVR1B) to activate SMAD-dependent signaling cascades. ACVR2B regulates processes like muscle growth, reproductive function, and embryonic development. Inhibition of ACVR2B has been explored as a therapeutic approach for muscle-wasting disorders, such as cachexia and muscular dystrophy. Mutations in ACVR2B can impair ligand-receptor interactions, leading to developmental defects.
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