Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit

715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501553
tested applications
ELISA
Description
Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 (ALKBH2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6NS38 |
| OMIM | 610602 |
| Alias | ALKBH2,ABH2 |
| Background | Elisa Kits for: ALKBH2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ALKBH2 is a key DNA repair enzyme that catalyzes the direct reversal of methylated lesions, particularly N1-methyladenine (m1A) and N3-methylcytosine (m3C), in double-stranded DNA. It is part of the alpha-ketoglutarate (α-KG)- and Fe(II)-dependent dioxygenase family, where it utilizes α-KG and molecular oxygen to demethylate damaged bases. ALKBH2 is essential for maintaining genomic integrity, as it repairs alkylation damage caused by environmental mutagens, chemotherapeutic agents, and endogenous metabolism. It operates in coordination with other DNA repair pathways to prevent mutations and DNA strand breaks. ALKBH2 is particularly active during DNA replication and cell division, ensuring faithful genome transmission. Mutations or dysregulation of ALKBH2 are associated with increased susceptibility to cancer and reduced cellular survival under genotoxic stress. Its function makes it a promising therapeutic target for enhancing the efficacy of alkylating agents in cancer treatment.
Related Products

Recombinant Human ALKBH2
Ver Producto
DNA Oxidative Demethylase ALKBH2 (ALKBH2) Antibody
ALKBH2 Antibody is a Rabbit Polyclonal Antibody against ALKBH2.
Ver Producto
Human DNA Oxidative Demethylase ALKBH2 (ALKBH2) Protein
ALKB Alkylation Repair Homolog 2 is a recombinant enzyme.
Ver Producto